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Collectively, studies from animal models demonstrated that the use of e-cigarettes during pregnancy is not safe and does lead to negative cardiovascular outcomes in the offspring (Fig

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16 In 2016, FDA promulgated regulations (known as "the deeming rule") that extended the agency's authority over all tobacco products that were not already subject to the FFDCA, including ENDS, cigars, pipe tobacco, hookah tobacco, nicotine gels, dissolvable tobacco, and other tobacco products that may be developed in the future